A primary component of cell signaling research, this title covers the principal membrane-bound receptor families, including their structural organization. Written and edited by experts in the field, this book provides up-to-date research on transmembrane signaling entities and their initiating responses following extracellular stimulation.

Table of Contents:
1. Cell Signaling: Yesterday, Today, and Tomorrow 2. Structural and Energetic Basis of Molecular Recognition 3. Free Energy Landscapes in Protein-Protein Interactions 4. Molecular Sociology 5. Antibody–Antigen Recognition and Conformational Changes 6. Binding Energetics in Antigen–Antibody Interfaces 7. Immunoglobulin–Fc Receptor Interactions 8. Ig-Superfold and its Variable Uses in Molecular Recognition 9. T Cell Receptor/pMHC Complexes 10. Mechanistic Features of Cell Surface Adhesion Receptors 11. The Immunological Synapse 12. NK Receptors 13. Carbohydrate Recognition and Signaling 14. Rhinovirus–Receptor Interactions 15. HIV-1 Receptor Interactions 16. Influenza Virus Neuraminidase Inhibitors 17. Structural Basis of Signaling Events Involving Fibrinogen and Fibrin 18. Structural Basis of Integrin Signaling 19. Structures of Heterotrimeric G Proteins and their Complexes 20. G-Protein-Coupled Receptor Structures 21. Toll-like Receptors – Structure and Signaling 22. Variable Lymphocyte Receptors 23. Structure and Function of G-Protein-Coupled Receptors: Lessons from Recent Crystal Structures 24. Chemokines and Chemokine Receptors: Structure and Function 25. The 2 Adrenergic Receptor as a Model for G-Protein-Coupled Receptor Structure and Activation 26. Protease-Activated Receptors 27. Agonist-Induced Desensitization and Endocytosis of G-Protein-Coupled Receptors 28. Functional Role(s) of Dimeric Complexes Formed from G-Protein-Coupled Receptors 29. Chemotaxis Receptors in Bacteria: Transmembrane Signaling, Sensitivity, Adaptation, and Clustering 30. An Overview of Ion Channel Structure 31. Molecular Mechanism of Store-Operated Ca2+ Signaling and CRAC Channel Activation Mediated 32. Ion Permeation: Mechanisms of Ion Selectivity and Block 33. Nicotinic Acetylcholine Receptors 34. Ion Channels Regulated by Direct Binding of Cyclic Nucleotides 35. Overview of Cytokine Receptors 36. Growth Hormone and Prolactin Family of Hormones and Receptors: The Structural Basis for Receptor Activation and Regulation 37. Erythropoietin Receptor as a Paradigm for Cytokine Signaling 38. The Fibroblast Growth Factor (FGF) Signaling Complex 39. Structure of IFN-g and its Receptors 40. Structure and Function of Tumor Necrosis Factor (TNF) at the Cell Surface 41. The Mechanism of NGF Signaling Suggested by the p75 and TrkA Receptor Complexes 42. The Mechanism of VEGFR Activation by VEGF 43 . Receptor–Ligand Recognition in the TGFb Superfamily as Suggested by Crystal Structures 44. Insulin Receptor Complex and Signaling by Insulin 45. Structure and Mechanism of the Insulin Receptor Tyrosine Kinase 46. IL-21 Increased Potency Desig 47. Signaling of IL-4R, a Typical Class I Cytokine Receptor: What Defines the Quiescent State? 48. Epidermal Growth Factor Kinases and their Activation in Receptor Mediated Signaling 49. Tumor Necrosis Factor Receptor-Associated Factors in Immune Receptor Signal Transduction 50. Assembly of Signaling Complexes for TNF Receptor Family Molecules 51. Mechanisms of CD40 Signaling in the Immune System 52. Role of Lipid Domains in EGF Receptor Signaling 53. Lipid-Mediated Localization of Signaling Proteins 54. Organization of Photoreceptor Signaling Complexes 55. Transmembrane Receptor Oligomerization