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Five-Lipoxygenase Products in Asthma: (Lung Biology in Health and Disease)

Five-Lipoxygenase Products in Asthma: (Lung Biology in Health and Disease)

          
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About the Book

Five-Lipoxygenase Products in Asthma offers an authoritative examination of the biochemistry, basic pharmacology, and clinical pharmacology of the leukotrienes with special emphasis on their role in asthma. A critical reference for every asthma researcher and clinician, Five-Lipoxygenase Products in Asthma highlights agents and products of the 5-LO pathway and its relationship to other pathways explores the enzymology of the 5-LO pathway with focus on leukotriene transport, degradation, and excretion details the role of protein identification in the 5-LO pathway describes human cell types that produce leukotrienes and their activation outlines pharmacological and binding study evidence for leukotriene receptors discusses the recovery of leukotrienes in lung disease analyzes leukotriene receptor antagonists and synthesis inhibitors by specific agent provides a by entity summary of individual drug information in exercise-induced, allergen-induced, aspirin-induced, and chronic stable asthma profiles the use of agents active on the 5-LO pathway in asthma treatment and more! With complete discussions of the recovery of leukotrienes in induced and spontaneous asthma and other conditions, Five-Lipoxygenase Products in Asthma, will benefit pulmonologists and pulmonary disease specialists; clinical allergists; internists; chest, intensive care, primary care, and family practice physicians; respiratory therapists; physiologists; pathologists; cell and molecular biologists; and graduate and medical school students in these disciplines.

Table of Contents:
Overview Overview of the 5-Lipoxygenase Pathway, Jesper Z. Haeggström and Bengt Samuelsson Leukotriene Biochemistry 5-Lipoxygenase and 5-Lipoxygenase-Activating Protein, Jilly F. Evans Leukotriene C4 Synthase: A Pivotal Enzyme in the Biosynthesis of Cysteinyl Leukotrienes, John F. Penrose and K. Frank Austen Leukotriene A4 Hydrolase, Jesper Z. Haeggström Leukotriene Export in Human Leukocytes, Bing K. Lam Cell Biology of the Leukotrienes Pathways of Leukotriene Metabolism in Isolated Cell Models and Human Subjects, Robert C. Murphy and Pat Wheelan Cell Biology of the 5-Lipoxygenase Pathway: Amplification and Generation of Leukotrienes and Lipoxins by Transcellular Biosynthesis, Timothy D. Bigby, Bruce D. Levy, and Charles N. Serhan Physiological Actions of the Leukotrienes Leukotriene Receptors: Incompletely Defined Targets for Treatment of Asthma and Inflammation, Sven-Erik Dahlén Physiological Effects of the Leukotrienes in Humans, Neil C. Barnes and Lewis J. Smith Recovery of Leukotrienes Analysis of Leukotrienes and Lipoxins, Graham W. Taylor Measurement of Leukotrienes from Human Biological Fluids, Jay Y. Westcott and Ian K. Taylor Leukotrienes in Asthma Cysteinyl-Leukotriene Receptor Antagonism and 5-Lipoxygenase Inhibition in Asthma, S. M. Shuaib Nasser and Tak H. Lee Leukotriene Receptor Antagonism and Synthesis in Chronic Stable Asthma, Elliot Israel and Jeffrey M. Drazen Specific Drug Products Montelukast-An Antileukotriene Treatment for Asthma: Changing the Asthma-Treatment Paradigm, Beth C. Seidenberg and Theodore F. Reiss Pranlukast-The First Orally Active Cysteinyl Leukotriene Receptor Antagonist Marketed for the Treatment of Asthma, Jeffrey W. Dubb and Anthony S. Rebuck Zafirlukast, Catherine M. Bonuccelli and Trevor J. C. Higgins Zileuton: The First Leukotriene Synthesis Inhibitor for Use in the Management of Chronic Asthma, Louise M. Dubé, Linda J. Swanson, Walid Awni, Rachel F. Ochs, Randy L. Bell, and George W. Carter Antileukotrienes in the Management of Asthma, Paul M. O'Byrne


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Product Details
  • ISBN-13: 9780824701673
  • Publisher: Taylor & Francis Inc
  • Publisher Imprint: CRC Press Inc
  • Height: 279 mm
  • No of Pages: 496
  • Returnable: N
  • Spine Width: 29 mm
  • Width: 216 mm
  • ISBN-10: 0824701674
  • Publisher Date: 17 Jul 1998
  • Binding: Hardback
  • Language: English
  • No of Pages: 496
  • Series Title: Lung Biology in Health and Disease
  • Weight: 816 gr


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