Kevan Shokat

Kevan ShokatProfessor Kevan is currently an Investigator of the Howard Hughes Medical Institute, Chair of the Department of Cellular and Molecular Pharmacology at UCSF and a Professor of Chemistry at UC Berkeley. He was inducted into the National Academy of Scieces (2010), the Institute of Medicine (2011), and the American Academy of Arts and Sciences (2011). His lab is most well-known for drugging the "undruggable" oncogene K-Ras (G12C) in 2013. In May of 2021 the drug sotorasib which binds to the same pocket on K-Ras (G12C) was approved for the treatment of lung cancer patients with this mutation. The field of K-Ras drug discovery is expanding quickly to hunt for drugs to target the other K-Ras mutants such as those which drive colon and pancreatic cancers which collectively represent almost 20% of all cancer patients world-wide. Kevan has been a co-founder of a number companies from their inception to public offering or acquisition and he is a co-founder of several currently private companies. Read More Read Less

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RAS Drug Discovery45 %
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Protein Kinase Inhibitors in Research and Medicine45 %
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Protein Kinase Inhibitors in Research and Medicine, Part B24 % NR
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Protein Kinase Inhibitors in Research and Medicine, Part a22 % NR
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Protein Kinase Inhibitors in Research and Medicine, Part BNR
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